A Rare Case of Primary Diffuse Large Cell Non Hodgkin's Lymphoma of Testis

Primary Testicular Lymphoma is a rare entity with an incidence of only 1-7% of all testicular neoplasms (1,3,5). It is the most common testicular tumour in elderly persons with an average age of 60-80 years, but it can also occur in children (2-5). Immunophenotypically, most of these tumours are B-cell type with diffuse large B-cell subtype being the most common (1-9). It is a unique tumour because of its rarity and poses a diagnostic and therapeutic challenge. Case Report 45 years old man presented with two months history of painless right testicular swelling which was progressively increasing in size. There was no history of trauma, night sweats, fever or chills. Scrotal examination revealed a firm and enlarged right testis. Examination of Abstract Primary testicular lymphomas (PTL) are rare entities representing 1-2% of Non-Hodgkin's Lymphoma (NHL) and 1-7% of malignant testicular tumours. They are most commonly seen in men older than 60 years. The most common type of primary testicular lymphoma (PTL) is diffuse large B-cell type which has the potential for aggressive clinical behaviour. We report the case of a 45 years old male with primary testicular lymphoma which was first diagnosed on Fine Needle Aspiration Cytology (FNAC) and subsequently confirmed histopathologically and immunophenotypically as Diffuse Large B-Cell Lymphoma (DLBCL) showing CD20 positivity. This case report confirms the literature data concerning the rarity of testicular Non Hodgkin's Lymphoma (TNHL) with DLBCL being the most common phenotype and the poor prognosis of the disease despite aggressive management.